CAS#: 77-52-1
Molecular formula: C30H48O3
Molecular weight: 456.68
Other names: Prunol, Malol, beta-Ursolic acid, 3-beta-hydroxyurs-12-en-28-oic acid
Botanical Source: Rosemarinus officinalis L.
KINGHERBS offer :25% to 98% Ursolic Acid
1.Anti-cancer
Ursolic acid is a kind of tritepene compound existing in natural plant with various kinds of biological effects such as sedation, anti inflammation, antibiosis, anti diabetes, antiulcer etc. In recent years, it has been found that it has functions of anticancer and antiangiogenesis. It possibly becomes one of the new type anticancer drugs with low toxicity and high efficiency. For strong antioxygen function, ursolic acid is widely used as material of medicine and cosmetics.
2.Anti-oxidant
Ursolic acid is a strong antioxidant.Some experiments have shown that ursolic acid can inhibit the activities of 5-lipopolysaccharide and cyclooxidase during the metabolism of arachidonic acid, and prevent the generation of prostaglanin and leukotriene, which may be the reason why ursolic acid can inhibit the inflammatory reaction and lipid peroxides.Subbaramaiah et al. showed that ursalic acid inhibited the transcription of cyclocyxase in human mammary epithelial cells and thus inhibited the production of prostatic hormone.The anti-oxidant effect of ursolic acid has positive effects on anti-aging, skin freckle removing and pigment removing.
3.Anti-bacterial and antiviral
Tapondjou et al. confirmed that ursolic acid and hydroxyursolic acid had similar anti-inflammatory and bacteriostatic effects through acetic acid twist experiment and hot plate experiment.Ursolic acid can inhibit the production of superoxide induced by formylmethionyl - leonyl - phenylalanine (fMLP) and arachidonic acid, respectively.Ursolic acid and fMLP were added to cell culture, and ursolic acid inhibited 45Ku protein tyrosine phosphorylation induced by fMLP in a dose-dependent manner.Ursolic acid also had trypanosomicidal activity. After incubation at a concentration of 2g·L for 2h, the activity of the flagellum of trypanosomium cragis was completely inhibited.
4.Anti-atherosclerosis
Ursolic acid can reduce blood cholesterol (44%) and B-lipoprotein (50%) in rabbits and rats, and has the effect of lowering blood lipid and resisting atherosclerosis. Ursolic acid can improve the liver and kidney Yin deficiency, tinnitus, dry mouth, lack of sleep, irritability and irritability, limb numbness and cold, constipation, constipation and constipation caused by dyslipidemia, etc., with a total effective rate of 95%.
5.HIV suppression
Human immunodeficiency virus (HIV) is the pathogenic factor of acquired immunodeficiency syndrome (AIDS).Tian Ying et al. demonstrated through clinical trials that ursolic acid had a strong inhibitory effect on the activity of HIV-1 protease, with an inhibitory concentration (IC50) of 8 mol/L.Hiv-1 protease is a homodimer enzyme, and ursolic acid may inhibit the activity of HIV-1 protease by inhibiting the dimerization of HIV-1 protease, thereby inhibiting the role of HIV protease.
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