A calming extract of green tea, theanine, is gaining a significant reputation among nutritional practitioners for its positive effects on anxiety. Other benefits, which are attributed to green tea's antioxidant epigallocatechin gallate (EGCG), include assistance in the fight against cancer and heart disease.
Theanine has had significant clinical results for naturally calming and focusing the brain. The nutrient seems to help center a mind that is often running in several different directions. Research is still limited in humans, but small studies have pointed to some antianxiety effect as well [Source: Kimura, Lu]. Patients typically describe effects as mild, but helpful. The soothing quality may also benefit those who aren't necessarily anxious, but can't relax the mind at night before sleep, and those with muscle tension in the neck.
Studies in animals indicate that theanine may also have protective effects for the brain [Source: Kakuda, Nathan]. It seems to protect the body from excess glutamate, a natural neurotransmitter that allows signaling between nerves. This chemical can be toxic to nerve tissue if levels are not regulated. Theanine shows some protective effects on nerve cells when there is decreased blood flow (caused by a stroke, etc.). Protection of brain cells could play an important role in illnesses that concurrently cause anxiety, such as Alzheimer's disease.
Cholesterol damaged by inflammation becomes much more toxic to the body. Theanine can help prevent this damage [Source: Yokozawa]. It has also been shown to enhance the effectiveness of various types of chemotherapy drugs in animal studies. This is extremely important, as anxiety is often a consequence of a cancer diagnosis. Theanine, as a supplement, can relieve anxiety brought on by treatment and actually complement some types of chemotherapy [Source: Sugiyama, Sadzuka].
Numerous in vitro and animal studies haveinvestigated L-theanines effect on cancer. Theaninedecreased the size of ovarian tumors in M5076 ovar-ian sarcoma-bearing mice, when given in conjunctionwith chemotherapeutics, size of ovarian tumors and decreased metastases tothe liver as well. In another study, theanine almostcarcinoma, while increasing the drugs, concentrationin tumor cells threefold. It appears theanine exertsan additive effect along with chemotherapy by re-ducing transport of glutamic acid into the cell, de-creasing GSH levels in the cell, and increasing theThis green tea offspring is well tolerated in supplement form. Hopefully, its antianxiety benefits will be confirmed through more clinical research. Theanine can aid those who have used heavier anxiety medications in the past. Though, an abrupt substitution is not advised. Products like Klonopin should be gradually reduced, under the guidance of a healthcare provider.concentration of the drug in tumor cells. Theaninealso protects normal cells from damage by chemo-therapeutic drugs.
Theanine is typically listed as L-theanine, with the "L" being a scientific notation of its structure. Typically dosing is 100-200 mg once to twice a day. Theanine should not affect driving abilities, but as with any anti-anxiety medication or supplement, one should use caution until all potential side effects have been exposed in a controlled environment.
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