High Standard 98% Resveratrol Polygonum Cuspidatum Extract

• Certification: ISO, FDA, HACCP, Kosher, Halal
• Assay Method: HPLC, UV
• Application: Medicine
• State: Liquid
• Name: Polygonum Cuspidatum Extract
• Type: Herbal Extract
• Model NO.: CAS NO.: 501-36-0
• Odor&Taste: Characteristic
• Part Used: Root & Rhizome
• Extraction Type: Solvent Extraction
• Sieve Analysis: 95% Pass Through 80 Mesh Sieve
• Grade: Pharmaceutical
• Latin Name: Rhizoma Polygoni Cuspidati
• Sample: Free
• Function: Anti-Cancer and to Strengthen Immunity
• Transport Package: in Fiber Drum, LDPE Bag Inside. N. W.: 25kgs/Drum
• Specification: ISO 9001, Kosher Certificate
• Trademark: KINGHERBS _ KH
• Origin: China_Kingherbs
• HS Code: 2938909090
• Production Capacity: 500kgs/Month

Product Description

Polygonum Cuspidatum Extract

Botanical Source: Polygonum cuspidatum; Reynoutria sachalinense
Part used: Root
Specification: Resveratrol 98% HPLC;
                       Polydatin 1%--99% HPLC;
                       Physcion 1% min. HPLC;
                       Emodin 1% --60% HPLC;                   

Description:
The protophyte of Polygonum is regarded as rhizome and root of Polygonum cuspidatum Sieb. et Zucc., perennial herbaceous, being one of the Chinese medicinal herbs most in use in ancient China.  
Cultivation: Fond of warm weather in nature, Polygonum better grows in moist & loose soil. Choose the arenaceous soil rich of humus when cultivating. It's also suitable to be cultivated by the ditch, in woodland of the hillside, and in front of or behind the house. Before soil preparation, apply tens of Kg of organic fertilizer per Mu. Plough the fields deep to 20-30cm. Prepare the earth as bed after ploughing.
Harvest:  Administration by root and rhizome, Polygonum can be digged both in spring and autumn. Root-like stem and stem, leaf are better to be gathered during spring and summer. And the root is better to be gathered in spring and autumn. Cut it to pieces while fresh after cleaning and then leave to dry in the sunshine. Those with strong root and non-withered inside are considerably as good ones. Remove the fibrous root and the tail, cut to pieces after cleaning, leave to dry in the sunshine, keep in dry places. Be cautious of mould-proof & worm-eaten. Prepared small pieces should be stored in wooden case and jar.
Distribution:Polygonum most grows in ravine, by the river and in shady-warm places under trees, mainly distributed in the south of Changjiang River, Shan'xi, Henan and Shandong provinces in China.
 
The main chemical composition
There are mainly anthraquinones, stilbenes, flavonoids, naphthoquinone, polysaccharides, amino acids and trace elements in Polygonum Cuspidatum.
(1) Anthraquinones: With two classifications in Polygonum:
1). dissociative chinones:Mainly as emodin, chrysophanol, rhein, physcion, questin & fallacinol. 
2). anthraquinonic glycoside: mainly as physcion-8-ß-D-glucoside & emodin-8-ß-D-glucoside.
3) Flavonoids:
Flavonoids in Polygonum contains glucofrangulin, quercetin, quercetin-3-arabinoside, quercetin-3-rhamnoside, quercetin-3-glucoside, quercetin-3-galactoside, luteolin-7-glucoside & three kinds of derivative of protocatechuic acid, (+)-catechin, 2,5-dimethyl-7-hydroxychromone in apigenin.
4) Naphthoquinone & anthraquinonic glycoside
There are 2-methoxy-6-acetylmethyljuglone & torachrysone-8-O-D-glucoside in naphthoquinone & anthraquinonic glycoside, which are isolated from Polygonum.
5) Other ingredients:
There are 7-hydroxy-4-methoxy-5-methylcoumarin  in Polygonum. Polygonum still contains of free amino acids, and inorganic elements such as Cu, Fe, Mn, Zn, K, Se & Mo, further with palmitate, stearic acid and arachidonic acid.
 
Functions:
Efficacy & mechanism to anti-cancer and to strengthen immunity: Resveratrol in Polygonum is the major active ingredient, which has effect to anti-cancer and to strengthen immunity through research. Resveratrol has very strong effect to clear oxidant free radical, along with inhibiting the damage and mutation to the body caused by free radical. Resveratrol has the optional power to cancer cells.
Resveratrol can inhibit protein tyrosine kinase, which is the material to make catalysis of tyrosine. Resveratrol's inhibition to protein tyrosine kinase is due to act on anti-mutation by inhibiting the function of kinase. The mechanism is mainly to inhibit the synthesis of cells of DNA and RNA.
Resveratrol has very strong inhibition to the reaction of lipid peroxidation caused by free radical system, also stronger inhibition to lipid peroxidation on the model of artificial cell of lecithin lipid. It can obviously reduce the content of MDA in the tissues, increase the activation of SOD, CAT and GSH-px, thus with protective effect to cerebral anaemia and tissue damages.
 
Resveratrol may strengthen the immunity. It can also recover the inhibited characteristic of cells in the burnt rat, with effective power to the reactive ability of damagedantigen singal, to breeding ability, to synthetic ability of white blood cell medium II and to synthetic ability of antibody through lymph cell.    

COA

Product Name		Polygonum Cuspidatum Extract	Batch Number		PCE-170831
Botanical Source		Polygonum cuspidatum	Batch Quantity		100kgs
Plant Part Used		Root,100% Natural	Country of Origin		China
Type of Product		Standard Extract	Active Ingredient Markers		Resveratrol
Analysis Items		Specifications	Results		Methods used
Identification		Positive	Conforms		TLC
Appearance		Fine White Powder	Conforms		Visual test
Odor & Taste		Characteristic	Conforms		Organoleptic test
Bulk Density		20-45g/100ml	Conforms		ASTM D1895B
Particle Size		NLT 98% through 80 Mesh	Conforms		AOAC 973.03
Solubility		Soluble in ethanol & water solution	Conforms		Visual
Assay		NLT 98% Resveratrol	98.10%		HPLC
Loss on Drying		NMT 1.0%	0.50%		5g / 105ºC / 2hrs
Ash Content		NMT 0.5%	0.08%		2g / 525ºC /3hrs
Extract Solvents		Ethanol & Water	Conforms		/
Solvent Residues		NMT 0.05%	Conforms		USP-GC
Excipients		None	Conforms		/
Heavy Metals		NMT 10ppm	Conforms		Atomic absorption
Arsenic (As)		NMT 1ppm	Conforms		Atomic absorption
Lead (Pb)		NMT 1ppm	Conforms		Atomic absorption
Cadmium (Cd)		NMT 1ppm	Conforms		Atomic absorption
Mercury(Hg)		NMT 0.1ppm	Conforms		Atomic absorption
666		NMT 0.1ppm	Conforms		USP-GC
DDT		NMT 0.5ppm	Conforms		USP-GC
Acephate		NMT 0.2ppm	Conforms		USP-GC
Methamidophos		NMT 0.2ppm	Conforms		USP-GC
Parathion-ethyl		NMT 0.2ppm	Conforms		USP-GC
PCNB		NMT 0.1ppm	Conforms		USP-GC
Aflatoxins		NMT 0.2ppb	Absent		USP-HPLC
Sterilization Method		High temperature & pressure for a short time of 5~10 seconds
Microbiological Data		Total Plate Count<1,000cfu/g	<100cfu/g		GB 4789.2
		Total Yeast & Mold<100cfu/g	<30cfu/g		GB 4789.15
		E. Coli to be negative	Negative		GB 4789.3
		Staphylococcus to be negative	Negative		GB 4789.4
		Salmonella to be absent	Absent		GB 4789.10
Packing and Storage		Packed in fiber drum, LDPE bag inside. Net weight: 25kgs/drum.
		Keep well sealed, away from moisture, strong heat and sunlight.
Shelf Life		2 years if sealed and stored in the recommended conditions.