Abstract:
Kava Kava Extract
Botanical Source: Piper methyticum L.
Part Used: Root
CAS No.: 9000-38-8
Molecular Formula: C21H26N2O3
Molecular Weight: 274.269
Specification: Kavalactones 30% 70% by HPLC
Functions:
Kava's active principal ingredients are the kavalactones, of which at least 15 have been identified and are all considered psychoactive. Only six of them produce noticeable effects, and their concentrations in kava plants vary. Different ratios can produce different effects. Desmethoxyyangonin, one of the six major kavalactones, is a reversible MAO-B inhibitor (Ki 280 nM) and is able to increase dopamine levels in the nucleus accumbens. This finding might correspond to the slightly euphoric action of kava.
Kava is used to calm anxiety, stress, and restlessness, and treat sleep problems (insomnia). It is also used for attention deficit-hyperactivity disorder (ADHD), epilepsy, psychosis, depression, migraines and other headaches, chronic fatigue syndrome (CFS), common cold and other respiratory tract infections, tuberculosis, muscle pain, and cancer prevention.
Some people use kava for urinary tract infections (UTIs), pain and swelling of the uterus, venereal disease, menstrual discomfort, and to arouse sexual desire.
| Analysis Items |
Specifications |
Results |
Methods used |
| Identification |
Positive |
Conforms |
TLC |
| Appearance |
Fine Yellow Powder |
Conforms |
Visual test |
| Odor & Taste |
Characteristic |
Conforms |
Organoleptic test |
| Bulk Density |
45-55g/100ml |
Conforms |
ASTM D1895B |
| Particle Size |
99% through 80 mesh |
Conforms |
AOAC 973.03 |
| Solubility |
100% soluble in water |
Conforms |
Visual |
| |
|
|
|
|
|
|
|
| Assay |
NLT 70% Kavalactones |
70.13% |
HPLC |
| Loss on Drying |
NMT 5.0% |
3.43% |
USP |
| Ash Content |
NMT 5.0% |
4.02% |
2g /525ºC /3hrs |
| Extract Solvents |
Water & Ethanol |
Conforms |
/ |
| Solvent Residues |
NMT 0.05% |
Conforms |
GC |
| |
|
|
|
|
|
|
|
| Heavy Metals |
NMT 10ppm |
Conforms |
Atomic Absorption |
| Arsenic (As) |
NMT 2ppm |
Conforms |
Atomic Absorption |
| Lead (Pb) |
NMT 2ppm |
Conforms |
Atomic Absorption |
| Cadmium (Cd) |
NMT 1ppm |
Conforms |
Atomic Absorption |
| Mercury(Hg) |
NMT 0.2ppm |
Conforms |
Atomic Absorption |
| |
|
|
|
|
|
|
|
| 666 |
NMT 0.1ppm |
Conforms |
GC |
| DDT |
NMT 0.5ppm |
Conforms |
GC |
| Acephate |
NMT 0.2ppm |
Conforms |
GC |
| |
|
|
|
| Parathion-ethyl |
NMT 0.2ppm |
Conforms |
GC |
| PCNB |
NMT 0.1ppm |
Conforms |
GC |
| |
|
|
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Characteristic:
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