Macleaya Cordata Extract
Botanical Source: Macleaya cordata (Willd.) R. Br.
Plant Part Used: Whole herb
Active Ingredients: Sanguinarine, Chelerythrine, protopine, α-Allocryptopine, β-Allocrytopine
Specification: Sanguinarine 0.2%-40%;
Description:
Macleaya cordata extract is a green pollution-free plant extract. Macleaya cordata contains several alkaloids including sanguinarine, chelerythrine, protopine, and allocryptopine. Sanguinarine and chelerythrine are the main components of it, which have fungicidal and insecticidal activity. Sanguinarine is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. It was been shown to be reversible inhibitors of the enzymatic hydrolysis of acetylthiocholine.
Sanguinarine is a toxic quaternary ammonium salt from the group of benzylisoquinoline alkaloids. It is extracted from some plants, including bloodroot (Sanguinaria canadensis), Mexican prickly poppy Argemone mexicana, Chelidonium majus and Macleaya cordata.
Sanguinarine is a toxin that kills animal cells through its action on the Na+-K+-ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine.
If applied to the skin, sanguinarine kills cells and may destroy tissue. In turn, the bleeding wound may produce a massive scab, called an eschar. For this reason, sanguinarine is termed anescharotic.
Preliminary pre-clinical in vitro and in vivo studies have demonstrated that sanguinarine causes apoptosis in human cancer cells, and recommend study of sanguinarine as a potential cancer treatment.A study conducted by the Case Western Reserve University in 2000 found that low doses of sanguinarine caused this apoptosis in cancerous human epidermoid carcinoma cells while little reaction from normal human skin cells was observed.
Functions:
Anti-inflammatory; anti-bacterial and antiviral;
Detoxifying and eliminating swelling;
Inhibitory effect on some bacteria and fungi;
Improving liver function, enhancing immunity;
killing maggot: can inhibit incubation of flyblow;
Insecticide: The three kinds of biological total base in the product can kill
nematodes, it can effectively inhibit bacteria and fungi;
It can be widely used in feed additive, bacteriostatic agent, pesticides, veterinary
drugs, disinfectant, etc
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