Artemisinin
The herb Artemisia annua L., locally known in Southeast Asia as "qing hao, " which is a member of the "Asteraccae" family. (Common names include "sweet wormwood" or "annual wormwood". )
Chemical characteristics:
ARTEMISININ/Arteannuin
Structure: C15H22O5
Molecular weight: 282.3
Artemisinin 99% HPLC
Chemical characteristics:
Lipophylic substance: Soluble in ethanol and hexane.
Description: White crystalline powder
CAS: 63968-64-9
Pharmacological properties: Antimalarial
Artemisinin acts as a blood schizontocide and therefore kills malaria parasites.
Artemisinin has been shown to work through oxygen and carbon based free radical mechanisms. Its structure includes an endoperoxide bridge. Peroxides generate free radicals in a Fenton type reaction when exposed to unbound ferrous iron. Malaria, which grows in the erythrocytes, has the opportunity to accumulate much excess iron which can spill into the unbound form. Electron microscopy has confirmed destruction of plasmodium membranes with morphology typical of free radical mechanisms.
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